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Education and Training
| PhD
| 1976
| City University of New York
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| MS
| 1971
| University of Massachusetts
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| BS
| 1969
| Brooklyn College
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Professor of Environmental Health Sciences, Mailman School of Public Health
and:
Director Epidemiology Program, Herbert Irving Comprehensive Cancer Center
Director Biomarkers Core Facility, Herbert Irving Comprehensive Cancer Center
Director,
Columbia Center for Environmental Health in Northern Manhattan
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| Dr. Regina Santella’s research involves the development of laboratory methods for the detection of human exposure to environmental and occupational carcinogens and their use in molecular epidemiology studies to identify causative factors, susceptible populations, and preventive interventions. Her work has allowed the determination of exposure to carcinogens by the measurement of their binding to DNA with highly specific and sensitive immunoassays using monoclonal and polyclonal antibodies that her laboratory has developed. These studies have demonstrated higher levels of DNA damage in those with environmental or occupational exposures and in subjects with breast, lung, and liver cancer compared to controls. In addition, the interaction between environmental exposures and genetic susceptibility on cancer risk is being investigated using high throughput genotyping to determine polymorphisms in carcinogen metabolism, oxidative stress, and DNA repair genes.
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