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Address
Imperial College Norfolk Place
London, W2 1PG
UK
Phone:020-759-43372
Email:[email protected]
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Adjunct Professor of Epidemiology, Mailman School of Public Health
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| Paolo Vineis is Chair of Environmental Epidemiology at Imperial College London, UK. He has been working in the field of cancer epidemiology for two decades. His current research examines the relationships between risk factors for cancer and the molecular mechanisms by which they exert their action (molecular epidemiology). In particular, he conducts research on genetic susceptibility related to DNA repair and the metabolism of carcinogenic substances, and on intermediate markers such as DNA adducts.
Such research is conducted in the context of site-specific case-control studies and in a large European cohort on diet and cancer, EPIC. The picture emerging from research in this field is (a) that intermediate markers such as adducts express both external exposure and individual susceptibility; (b) that adducts predict the risk of cancer; (c) that the role of genetic susceptibility, in particular of DNA repair polymorphisms, might be more important at low than at high levels of external dose.
In addition, he has a strong interest in philosophical issues related to causality in medicine, a subject on which he has written a book (P. Vineis : Modelli di rischio. La causalità in epidemiologia. Einaudi, Torino, 1990) and several papers (see for example Vineis P.: Definition and classification of cancer: monothetic or polythetic? Theoretical Medicine 14; 249-256, 1993; Vineis P.: Proof in observational medicine. J Epidemiol Community Health 51; 9-13, 1997).
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