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Address
PI Annex 114, 722 West 168th St.
New York, NY 10032
Phone:212-342-0457
Email:[email protected]
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| University Affiliations |
| ▪ | Cancer Center |
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Education and Training
| PhD
| 1981
| University of Missouri
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| BS
| 1976
| University of Cincinnati
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Associate Professor of Clinical Environmental Health Sciences (Cell Biology and Pathobiology), Mailman School of Public Health
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| Greg Freyer’s major research interest is in understanding the cell’s response to environmental agents that damage DNA. His research focuses on the recQ DNA helicases family of enzymes and their interaction with proteins of the homologous recombination pathway that work together in the repair of DNA double strand breaks and recovery from stalled replication, both potentially lethal and mutagenic events. Studies in the laboratory are beginning to unravel the complex set of molecular events that are critical for maintaining genomic stability following DNA damage. He and his team of researchers have found a role for RecQ helicases in both the determination of the mechanism of DNA repair and in blocking crossover formation. In collaboration with other experts in environmental health sciences, his group is also investigating whether a polymorphic form of the DNA repair protein XRCC1, shown to increase p53 mutation rates, is defective in its biochemical activity. Dr Freyer is director of Academic Affairs for the Department Environmental Health Sciences, serves as chair of the Steering Committee, the faculty representative on the MSPH Strategic Planning Committee, and is active on several other committees including, the subcommittee on Diversity, the subcommittee on Doctoral Policy and Planning, the Summer Research Program for Science Teachers. Dr Freyer holds a joint appointment in the Department of Cell Biology and Pathobiology.
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