Course Description Prerequisites: P8104, P8175, working knowledge of calculus, and the instructor�s permission. This course explores the theoretical foundations underlying the models and techniques used in mathematical genetics and genetic epidemiology. Topics include use and interpretation of likelihood methods, formulation of mathematical models, segregation analysis, ascertainment bias, linkage analysis, genetic heterogeneity, and complex genetic models. The course includes lectures, discussions, homework problems, and a final exam. My single most important objective for this course is for students to be able to break down any mathematical modeling problem logically into all its component parts, to express each “part” accurately, and to know how to “add” all the pieces back up and to check the accuracy of their result. |
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